Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.

@article{Santini2001ChangesID,
  title={Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.},
  author={Valeria Santini and Hagop M Kantarjian and Jean-Pierre Issa},
  journal={Annals of internal medicine},
  year={2001},
  volume={134 7},
  pages={573-86}
}
Methylation of DNA is a biochemical modification that can influence gene expression and is involved in inactivating one of the two X chromosomes in women. Evidence that has accumulated in the past 10 years suggests that cancer cells usurp this physiologic mechanism and use it to their benefit by inactivating tumor suppressor genes and related proteins. However, the primary structure of the affected proteins remains intact; reversal of abnormalities in DNA methylation may therefore restore the… CONTINUE READING