Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB Proteins

@article{Holloway2003ChangesIC,
  title={Changes in Chromatin Accessibility Across the GM-CSF Promoter upon T Cell Activation Are Dependent on Nuclear Factor κB Proteins},
  author={Adele F Holloway and Sudha Rao and Xinxin Chen and M. Frances Shannon},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={413 - 423}
}
  • Adele F Holloway, Sudha Rao, +1 author M. Frances Shannon
  • Published in
    The Journal of experimental…
    2003
  • Medicine, Biology
  • Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a key cytokine in myelopoiesis and aberrant expression is associated with chronic inflammatory disease and myeloid leukemias. This aberrant expression is often associated with constitutive nuclear factor (NF)-kappaB activation. To investigate the relationship between NF-kappaB and GM-CSF transcription in a chromatin context, we analyzed the chromatin structure of the GM-CSF gene in T cells and the role of NF-kappaB proteins in… CONTINUE READING

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