Changes in Brain Function Occur Years before the Onset of Cognitive Impairment

  title={Changes in Brain Function Occur Years before the Onset of Cognitive Impairment},
  author={L. Beason-Held and J. Goh and Y. An and M. Kraut and R. O'brien and L. Ferrucci and S. Resnick},
  journal={The Journal of Neuroscience},
  pages={18008 - 18014}
  • L. Beason-Held, J. Goh, +4 authors S. Resnick
  • Published 2013
  • Psychology, Medicine
  • The Journal of Neuroscience
  • To develop targeted intervention strategies for the treatment of Alzheimer's disease, we first need to identify early markers of brain changes that occur before the onset of cognitive impairment. Here, we examine changes in resting-state brain function in humans from the Baltimore Longitudinal Study of Aging. We compared longitudinal changes in regional cerebral blood flow (rCBF), assessed by 15O-water PET, over a mean 7 year period between participants who eventually developed cognitive… CONTINUE READING

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