Changes in Brain Function Occur Years before the Onset of Cognitive Impairment

@article{BeasonHeld2013ChangesIB,
  title={Changes in Brain Function Occur Years before the Onset of Cognitive Impairment},
  author={L. Beason-Held and J. Goh and Y. An and M. Kraut and R. O'brien and L. Ferrucci and S. Resnick},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={18008 - 18014}
}
  • L. Beason-Held, J. Goh, +4 authors S. Resnick
  • Published 2013
  • Psychology, Medicine
  • The Journal of Neuroscience
  • To develop targeted intervention strategies for the treatment of Alzheimer's disease, we first need to identify early markers of brain changes that occur before the onset of cognitive impairment. Here, we examine changes in resting-state brain function in humans from the Baltimore Longitudinal Study of Aging. We compared longitudinal changes in regional cerebral blood flow (rCBF), assessed by 15O-water PET, over a mean 7 year period between participants who eventually developed cognitive… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
    • 17
    • Highly Influenced
    • PDF
    Reduced Regional Cerebral Blood Flow Relates to Poorer Cognition in Older Adults With Type 2 Diabetes
    • 21
    • Highly Influenced
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 57 REFERENCES
    One-year age changes in MRI brain volumes in older adults.
    • 473
    • PDF
    Structural and functional MRI in mild cognitive impairment.
    • 87
    Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
    • 2,038
    • PDF
    Longitudinal Cerebral Blood Flow and Amyloid Deposition: An Emerging Pattern?
    • 57
    • PDF
    Functional deactivations: Change with age and dementia of the Alzheimer type
    • 653
    • Highly Influential
    • PDF
    Spatial patterns of intrinsic brain activity in mild cognitive impairment and alzheimer's disease: A resting‐state functional MRI study
    • 191
    Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
    • 870
    • PDF