Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging

  title={Changes in Apoptosis and Cell Proliferation in Human Pineal Gland during Aging},
  author={Victoria O. Polyakova and Natalia Linkova and S. Pichugin},
  journal={Bulletin of Experimental Biology and Medicine},
Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. Moreover, pinealocyte apoptosis is more pronounced in elderly, whereas in senile and long-living individuals its intensity decreases. 

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