Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

@article{Frey2006ChangesIA,
  title={Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania},
  author={Benicio N. Frey and Samira S Valvassori and Gislaine Zilli R{\'e}us and M{\'a}rcio Martins and Fabricia Petronilho and Katrine C Bardini and Felipe Dal-Pizzol and Fl{\'a}vio Kapczinski and Jo{\~a}o Quevedo},
  journal={Neurochemical Research},
  year={2006},
  volume={31},
  pages={699-703}
}
Studies have demonstrated that oxidative stress is associated with amphetamine-induced neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after amphetamine exposure. We studied the effects of acute and chronic amphetamine administration on superoxide dismutase (SOD) and catalase (CAT) activity, in a rodent model of mania. Male Wistar rats received either a single IP injection of d-amphetamine (1 mg/kg, 2 mg/kg, or 4 mg/kg) or vehicle (acute treatment… CONTINUE READING

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