Changes in Abundance of Oral Microbiota Associated with Oral Cancer

  title={Changes in Abundance of Oral Microbiota Associated with Oral Cancer},
  author={Brian L. Schmidt and Justin Kuczynski and Aditi Bhattacharya and Bing Huey and Patricia M. Corby and Erica L. S. Queiroz and Kira Nightingale and Alexander Ross Kerr and Mark D Delacure and Ratna Veeramachaneni and Adam B. Olshen and Donna Albertson},
  booktitle={PloS one},
Individual bacteria and shifts in the composition of the microbiome have been associated with human diseases including cancer. To investigate changes in the microbiome associated with oral cancers, we profiled cancers and anatomically matched contralateral normal tissue from the same patient by sequencing 16S rDNA hypervariable region amplicons. In cancer samples from both a discovery and a subsequent confirmation cohort, abundance of Firmicutes (especially Streptococcus) and Actinobacteria… CONTINUE READING
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