Change of bone tissue composition and impaired bone strength in rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126).

@article{Lind2000ChangeOB,
  title={Change of bone tissue composition and impaired bone strength in rats exposed to 3,3',4,4',5-pentachlorobiphenyl (PCB126).},
  author={P Monica Lind and Sune Larsson and H R Witek Oxlund and Helen H{\aa}kansson and Karin Nyberg and Teresa Eklund and Jan A Orberg},
  journal={Toxicology},
  year={2000},
  volume={150 1-3},
  pages={41-51}
}
The aim of this study was to compare effects of estrogen depletion (ovariectomy) and exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB126) on bone strength and bone tissue composition in the rat. Half of the rats were ovariectomized (n=20) and the remainder were sham-operated. Ten of the ovariectomized rats and ten of the sham operated were exposed to PCB126 (ip injections) for 3 months (total dose, 384 microgram/kg bodyweight), while those remaining received the vehicle. The humerus and femur… CONTINUE READING

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