Change in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation.

@article{Ando1995ChangeIV,
  title={Change in variant transthyretin levels in patients with familial amyloidotic polyneuropathy type I following liver transplantation.},
  author={Y Ando and Yuji Tanaka and Mio Nakazato and Bo G{\"o}ran Ericzon and Taro Yamashita and Kazuhiro Tashima and Naomi Sakashita and Moritaka Suga and Makoto Uchino and Masayuki Ando},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={211 2},
  pages={354-8}
}
Three patients with familial amyloidotic polyneuropathy (FAP) type I underwent liver transplantation from heart-beating cadaveric donors. Since 2 patients underwent blood transfusion during the operation, variant transthyretin (TTR) levels in the plasma did not decrease time dependently. However, in 1 patient without blood transfusion variant TTR levels decreased in a time dependent manner and plasma half life of variant TTR was calculated to be 2.1 days. Total protein, normal, and variant TTR… CONTINUE READING

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