Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.

@article{Rami2006ChangeIT,
  title={Change in the shape and density of dendritic spines caused by overexpression of acidic calponin in cultured hippocampal neurons.},
  author={Guillaume Rami and Olivier Caillard and Igor Medina and Christophe Pellegrino and Abdellatif Fattoum and Yezekiel Ben-Ari and Lotfi Ferhat},
  journal={Hippocampus},
  year={2006},
  volume={16 2},
  pages={183-97}
}
Dendritic spines are morphing structures believed to provide a cellular substrate for synaptic plasticity. It has been suggested that the actin cytoskeleton is the target of molecular mechanisms regulating spine morphology. Here we hypothesized that acidic calponin, an actin-binding protein, is one of the key regulators of actin filaments during spine plasticity. Our data showed that the overexpression of acidic calponin-GFP (green fluorescent protein) in primary cultures of rat hippocampal… CONTINUE READING

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