Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.

Abstract

The activity of cyclic AMP-dependent protein kinase (protein kinase A) in the sensitized rat mast cell was decreased 2 min after antigen challenge when the histamine release exhibited a maximum. Drugs inhibiting allergic mediator release such as disodium cromoglycate, tranilast and theophylline significantly inhibited antigen-induced histamine release and… (More)

Topics

Cite this paper

@article{Kurosawa1987ChangeIT, title={Change in the activity of the cyclic AMP-dependent protein kinase in antigen-stimulated sensitized mast cells and effect of drugs inhibiting allergic mediator release.}, author={Manabu Kurosawa and H. Mori and H. Nagai and A. Akihide Koda}, journal={Japanese journal of pharmacology}, year={1987}, volume={43 4}, pages={454-7} }