Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.

@article{Tikoo2008ChangeIP,
  title={Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy.},
  author={Kulbhushan Tikoo and Ratti Lal Meena and Dhiraj G. Kabra and Anil Bhanudas Gaikwad},
  journal={British journal of pharmacology},
  year={2008},
  volume={153 6},
  pages={1225-31}
}
BACKGROUND AND PURPOSE Curcumin has been used to treat cancer, diabetes and other pathologies. However, little is known regarding its role in altering post-translational modifications of histone H3. A recent report suggests that acute hyperglycaemia induces a global down-regulation of gene expression in human tissues and epigenetic regulation of gene expression could be a novel mechanism underlying the pathological processes of hyperglycaemia. The present study was undertaken to examine changes… CONTINUE READING

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