Change in organotropism of mouse lymphoma variants associated with selective chemotactic responsiveness to organ-derived chemoattractants

@article{Benke1991ChangeIO,
  title={Change in organotropism of mouse lymphoma variants associated with selective chemotactic responsiveness to organ-derived chemoattractants},
  author={Rosemarie Benke and Volker Schirrmacher},
  journal={Clinical & Experimental Metastasis},
  year={1991},
  volume={9},
  pages={205-219}
}
A variant of the highly metastatic mouse lymphoma ESb was isolated from ESb suspension culture by repeated selection for adhesiveness to plastic. The adhesion variant ESb-MP was shown to have greatly reduced malignant potential and a change in organotropism. ESb-MP cells metastasized into the kidney with a high frequency (80% of mice), whereas the ESb cells only rarely infiltrated the kidney (4% of mice). Two subclones of the adherent variant (ESb-M2 A8, ESb-M2 H6) showed a reduced malignant… CONTINUE READING