Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia.

@article{Crowley2004ChangeIN,
  title={Change in nuclear-cytoplasmic localization of a double-bromodomain protein during proliferation and differentiation of mouse spinal cord and dorsal root ganglia.},
  author={ThomasE Crowley and Michele Brunori and Kunsoo Rhee and Xiangyuan Wang and Debra J. Wolgemuth},
  journal={Brain research. Developmental brain research},
  year={2004},
  volume={149 2},
  pages={93-101}
}
The human Brd2 (Bromodomain-containing 2) gene codes for a double-bromodomain protein that associates with the cell cycle-driving transcription factors E2F-1 and E2F-2. Expression of mouse Brd2 has been shown previously to be expressed in specific patterns in proliferating cells in the developing alveoli in the mammary gland. In the present study, in situ hybridization and immunohistochemical analyses were used to examine expression of Brd2 in developing neural tissues. Brd2 mRNA was detected… CONTINUE READING
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