Change in moles linked to use of unlicensed “sun tan jab”

  title={Change in moles linked to use of unlicensed “sun tan jab”},
  author={Ewan A Langan and Denise Ramlogan and Lynne A Jamieson and Lesley E Rhodes},
  journal={BMJ : British Medical Journal},
We draw attention to a new factor complicating presentation and diagnosis of pigmented lesions1: unlicensed use of melanotropic peptides offered online as Melanotan I and II. Two patients presented to our dermatology clinic with rapidly changing moles and a conspicuous tan, despite their sun reactive skin type I/II (sunburns easily, suntans poorly). They were both sunbed users. One, a woman of 42, reported two moles on her … 
Changes of melanocytic lesions inducedby Melanotan injections and sun bed use ina teenage patient with FAMMM syndrome
  • G. Sivyer
  • Medicine
    Dermatology practical & conceptual
  • 2012
A 16-year-old girl presented with general skin tanning, multiple dark melanocytic nevi and an enlarging nevus in her left groin following self-injections of Melanotan 2 and attending a UV tanning
Eruptive naevi and darkening of preexisting naevi 24 h after a single mono-dose injection of melanotan II
A 24-year-old male bodybuilder reported the eruption of multiple new naevi and darkening of pre-existing naevi 24 h after a single subcutaneous injection of illegally acquired melanotan II.
An eruptive pigmented lesion after melanotan injection
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Cutaneous porphyrias part II: treatment strategies
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Melanotropic peptides: more than just ‘Barbie drugs’ and ‘sun‐tan jabs’?
Subcutaneous self‐administration of unregulated products labelled as melanotan I and/or II, synthetic analogues of α‐melanocyte stimulating hormone (α‐MSH), as obtained via the internet, tanning salons and gyms and of the potential impurity of these products await full determination.
Melanotropic peptides: what exactly is meant by "melanotan"?
Dermatologists need to be aware of the increasing self-medication by the public of melanotropic peptides, and the presence of an unexpected tan may alert the physician to their use, as well as drawing attention to the fact that " melanotan " is not synonymous with " melatonin.
Eruptive melanocytic naevi following melanotan injection
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Melanotan II injection resulting in systemic toxicity and rhabdomyolysis
A 39 year-old Caucasian male injected subcutaneously 6 mg of Melanotan II purchased over the Internet in an attempt to darken his skin during wintertime resulted in systemic toxicity including apparent sympathomimetic symptoms, rhabdomyolysis, and renal dysfunction.
Update on tanning: More risks, fewer benefits.
Eruptive Dysplastic Nevi Following Melanotan Use
The case of a 25-year-old man who came to the department for the sudden eruption of multiple melanocytic nevi and rapid transformation of existing nevi is reported, which occurred a few weeks after a 4-week course of subcutaneous Melanotan II.


Effects of a superpotent melanotropic peptide in combination with solar UV radiation on tanning of the skin in human volunteers.
Melanotan-1 can be safely combined with UV-B light or sunlight and appears to act synergistically in the tanning response to light.
[Nle4-D-Phe7]-alpha-melanocyte-stimulating hormone significantly increased pigmentation and decreased UV damage in fair-skinned Caucasian volunteers.
The potential ability of a synthetic hormone that augments melanin production to provide photoprotection to people who normally burn in direct sunlight is shown for the first time.
Melanoma—Part 2: management
The management of patients with incurable disease is highly specialised and requires the input of surgeons, medical and clinical oncologists, palliative care teams, and clinical nurse specialists.