Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression.

@article{Papas1999ChangeIL,
  title={Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression.},
  author={Klearchos K Papas and Lanying Sun and Eric S Roos and John S Gounarides and Mika Shapiro and Carlo M. Nalin},
  journal={FEBS letters},
  year={1999},
  volume={446 2-3},
  pages={338-42}
}
As a result of Myc-dependent transcription of the LDH-A gene, Myc-transformed cells (Rat1-Myc) exhibit increased lactate production rates (LPR) even under aerobic conditions (the Warburg effect). Recently, the increased susceptibility to stress-induced apoptosis associated with Myc transfection has been linked to the overexpression of the LDH-A gene. In… CONTINUE READING