Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702.

@article{Khaliq2009ChangeIC,
  title={Change in colony morphology and kinetics of tylosin production after UV and gamma irradiation mutagenesis of Streptomyces fradiae NRRL-2702.},
  author={Shazia Khaliq and Kalsoom Akhtar and Muhammad Afzal Ghauri and Rehana Iqbal and Ahmad Mukhtar Khalid and Muhammad Muddassar},
  journal={Microbiological research},
  year={2009},
  volume={164 4},
  pages={
          469-77
        }
}
Tylosin is a macrolide antibiotic used as veterinary drug and growth promoter. Attempts were made for hyper production of tylosin by a strain of Streptomyces fradiae NRRL-2702 through irradiation mutagenesis. Ultraviolet (UV) irradiation of wild-type strain caused development of six morphologically altered colony types on agar plates. After screening using Bacillus subtilis bioassay only morphological mutants indicated the production of tylosin. An increase of 2.7+/-0.22-fold in tylosin… CONTINUE READING
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