Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats.

@article{Creutzenberg2012ChangeIA,
  title={Change in agglomeration status and toxicokinetic fate of various nanoparticles in vivo following lung exposure in rats.},
  author={Otto H Creutzenberg and B. Bellmann and Regina Korolewitz and Wolfgang Koch and Inge Mangelsdorf and Thomas Tillmann and Dirk Schaudien},
  journal={Inhalation toxicology},
  year={2012},
  volume={24 12},
  pages={821-30}
}
The deposition characteristics in lungs following inhalation, the potential toxic effects induced and the toxicokinetic fate including a possible translocation to other sites of the body are predominantly determined by the agglomeration status of nanoscaled primary particles. Systemic particle effects, i.e. effects on remote organs besides the respiratory tract are considered to be of relevant impact only for de-agglomerated particles with a nanoscaled aspect. Rats were exposed to various types… CONTINUE READING

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