Change in Intracellular pH Causes the Toxic Ca2+ Entry via NCX1 in Neuron- and Glia-Derived Cells

@article{Shono2009ChangeII,
  title={Change in Intracellular pH Causes the Toxic Ca2+ Entry via NCX1 in Neuron- and Glia-Derived Cells},
  author={Yuji Shono and Masahiro Kamouchi and Takanari Kitazono and Junya Kuroda and Kuniyuki Nakamura and Noriko Hagiwara and Hiroaki Ooboshi and Setsuro Ibayashi and Mitsuo Iida},
  journal={Cellular and Molecular Neurobiology},
  year={2009},
  volume={30},
  pages={453-460}
}
Brain hypoxia or ischemia causes acidosis and the intracellular accumulation of Ca2+ in neuron. The aims of the present study were to elucidate the interaction between intracellular pH and Ca2+ during transient acidosis and its effects on the viability of neuronal and glial cells. Intracellular Ca2+ and pH were measured using the fluorescence of fura-2 and 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester in neuroblastoma (IMR-32), glioblastoma (T98G), and astrocytoma (CCF… CONTINUE READING

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