Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals

@article{Connor1997ChangeIC,
  title={Change in Coreceptor Use Correlates with Disease Progression in HIV-1–Infected Individuals},
  author={Ruth I. Connor and Kristine E. Sheridan and Daniel J Ceradini and Sunny S. Choe and Nathaniel R. Landau},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={185},
  pages={621 - 628}
}
Recent studies have identified several coreceptors that are required for fusion and entry of Human Immunodeficiency Virus type 1 (HIV-1) into CD4+ cells. One of these receptors, CCR5, serves as a coreceptor for nonsyncytium inducing (NSI), macrophage-tropic strains of HIV-1, while another, fusin or CXCR-4, functions as a coreceptor for T cell line-adapted… CONTINUE READING