Chances and pitfalls of cell penetrating peptides for cellular drug delivery.

@article{Trhin2004ChancesAP,
  title={Chances and pitfalls of cell penetrating peptides for cellular drug delivery.},
  author={Rachel Tr{\'e}hin and Hans Peter Merkle},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2004},
  volume={58 2},
  pages={209-23}
}
Over the past decade, several classes and/or prototypes of cell penetrating peptides (CPP) have been identified and investigated in multiple aspects. CPP represent peptides, which show the ability to cross the plasma membrane of mammalian cells, and may thus give rise to the intracellular delivery of problematic therapeutic cargos, such as peptides, proteins, oligonucleotides, plasmids and even nanometer-sized particles, which otherwise cannot cross the plasma membrane. Most of the currently… CONTINUE READING

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