Chance factors in studies of quantitative structure-activity relationships.

@article{Topliss1979ChanceFI,
  title={Chance factors in studies of quantitative structure-activity relationships.},
  author={J G Topliss and Robert Edwards},
  journal={Journal of medicinal chemistry},
  year={1979},
  volume={22 10},
  pages={1238-44}
}
Multiple regression analysis is a basic statistical tool used for QSAR studies in drug design. However, there is a risk or arriving at fortuitous correlations when too many variables are screened relative to the number of available observations. In this regard, a critical distinction must be made between the number of variables screened for possible… CONTINUE READING