Chance and necessity in the evolution of minimal metabolic networks

@article{Pl2006ChanceAN,
  title={Chance and necessity in the evolution of minimal metabolic networks},
  author={C. P{\'a}l and B. Papp and M. Lercher and P. Csermely and S. Oliver and L. Hurst},
  journal={Nature},
  year={2006},
  volume={440},
  pages={667-670}
}
It is possible to infer aspects of an organism's lifestyle from its gene content. Can the reverse also be done? Here we consider this issue by modelling evolution of the reduced genomes of endosymbiotic bacteria. The diversity of gene content in these bacteria may reflect both variation in selective forces and contingency-dependent loss of alternative pathways. Using an in silico representation of the metabolic network of Escherichia coli, we examine the role of contingency by repeatedly… Expand

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