Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.

@article{Miotto2006ChameauHA,
  title={Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.},
  author={Beno{\^i}t Miotto and Thierry Sagnier and H{\'e}l{\`e}ne B{\'e}renger and Dirk Bohmann and Jacques Pradel and Yacine Graba},
  journal={Genes & development},
  year={2006},
  volume={20 1},
  pages={
          101-12
        }
}
Gene regulation by AP-1 transcription factors in response to Jun N-terminal kinase (JNK) signaling controls essential cellular processes during development and in pathological situations. Here, we report genetic and molecular evidence that the histone acetyltransferase (HAT) Chameau and the histone deacetylase DRpd3 act as antagonistic cofactors of DJun and DFos to modulate JNK-dependent transcription during thorax metamorphosis and JNK-induced apoptosis in Drosophila. We demonstrate in… CONTINUE READING
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