Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy.

@article{Boehm1998ChamberspecificAO,
  title={Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy.},
  author={Michael Boehm and Maurizio Castellano and Markus Flesch and Christoph Maack and Maciej Moll and Magnus Paul and Frank Schiffer and Oliver Zolk},
  journal={Hypertension},
  year={1998},
  volume={32 5},
  pages={831-7}
}
The present study investigated local differences of sympathetic activation and sympathetic neuroeffector defects in nonhypertrophied right and hypertrophied left ventricles in a rat model with renin-induced pressure overload [TG(mREN2)27]. As judged from the depletion of myocardial norepinephrine stores, sympathetic activation was more pronounced in the left than in the right ventricles. In addition, norepinephrine uptake1 carrier sites were reduced in left but unchanged in right ventricles… CONTINUE READING
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Evidence for a reduction of norepinephrine uptake sites in the failing human heart

  • M Böhm, K La Rosée, RHG Schwinger, E. Erdmann
  • J Am Coll Cardiol
  • 1995

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