Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

@article{Wang2015ChamaejasminBE,
  title={Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway},
  author={Ya Wang and Qi Li and Hong-bin Xiao and Yu Jie Li and Qing Yang and Xiao-xi Kan and Ying Chen and Xiao Liu and Xiao-gang Weng and Xi Chen and Wei-yan Cai and Yan Guo and He-fei Huang and Xiao Xin Zhu},
  journal={Drug Design, Development and Therapy},
  year={2015},
  volume={9},
  pages={5301 - 5313}
}
  • Ya Wang, Qi Li, X. X. Zhu
  • Published 22 September 2015
  • Biology, Chemistry
  • Drug Design, Development and Therapy
Multidrug resistance (MDR) is the main obstacle limiting the efficacy of cancer chemotherapy. Looking for novel anti-MDR agents is an important way to conquer cancer drug resistance. We recently established that chamaejasmin B (CHB), a natural biflavone from Stellera chamaejasme L., is the major active component. However, its anti-MDR activity is still unknown. This study investigated the anti-MDR effect of CHB and the underlying mechanisms. First, it was found that CHB inhibited the growth of… 
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References

SHOWING 1-10 OF 45 REFERENCES
Synthesis of a Dual Functional Anti-MDR Tumor Agent PH II-7 with Elucidations of Anti-Tumor Effects and Mechanisms
TLDR
PH II-7 is a dual-functional compound that features both the cytotoxicity against cancer cells and the inhibitory effect on P-gp mediated drug efflux.
In vitro anti-cancer activity of chamaejasmenin B and neochamaejasmin C isolated from the root of Stellera chamaejasme L
TLDR
Chamaejasmenin B and neochAMAejasmin C are potential anti-proliferative agents in 8 human solid tumor cell lines in vitro via inducing cell cycle arrest, apoptosis and DNA damage.
In vitro inhibitory and pro-apoptotic effect of Stellera chamaejasme L extract on human lung cancer cell line NCI-H157.
Inhibitory Effects of Neochamaejasmin B on P-Glycoprotein in MDCK-hMDR1 Cells and Molecular Docking of NCB Binding in P-Glycoprotein
TLDR
To characterize the inhibition of neochamaejasmin B (NCB) on P-glycoprotein (P-gp, ABCB1, MDR1), docking data indicated that NCB had higher affinity to P-gp than to Lig1 ((S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one).
Stellera chamaejasme L. extract induces apoptosis of human lung cancer cells via activation of the death receptor-dependent pathway
TLDR
It is found that ESC-2 inhibited the growth of NCI-H157 cells, demonstrating ESC-1-induced morphological changes in cells and reduced cell viability in a dose- and time-dependent manner, indicating that the NCI/H157 cell growth inhibitory activity of ESC was due to death receptor-dependent pathway-mediated apoptosis.
Anti-tumor pharmacological evaluation of extracts from stellera chamaejasme L based on hollow fiber assay
TLDR
ESC-2 had the similar antitumor effect to that of ESC in vivo and further confirmed that ESC-2 may be the main antitumors active fraction of ESC, which was consistent with the previous results in vitro.
Inhibitory effects of Lang-du extract on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action
TLDR
It is shown that LDE significantly suppressed the in vitro melanoma cell growth in dose- and time-dependent manners, and may have a wide therapeutic and/or adjuvant therapeutic application in the treatment of melanoma and other cancer.
Chamaejasmine Arrests Cell Cycle, Induces Apoptosis and Inhibits Nuclear NF-κB Translocation in the Human Breast Cancer Cell Line MDA-MB-231
TLDR
The findings suggested that chamaejasmine could be explored as a preventive and perhaps as a chemotherapeutic agent in the management of breast cancer.
[Antitumor effect of alcohol extracts from Stellera chamaejasme].
TLDR
The biflavonoids in alcohol extracts from S. chamaejasme have exerted a satisfactory inhibitory effect on the lung cancer cell proliferation.
Molecular mechanisms of drug resistance and its reversal in cancer
TLDR
This review comprises the mechanisms guiding multidrug resistance in cancer chemotherapy and also touches on approaches for reversing the resistance.
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