Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway

  title={Chamaejasmin B exerts anti-MDR effect in vitro and in vivo via initiating mitochondria-dependant intrinsic apoptosis pathway},
  author={Ya Wang and Qi Li and Hong-bin Xiao and Yu Jie Li and Qing Yang and Xiao-xi Kan and Ying Chen and Xiao Liu and Xiao-gang Weng and Xi Chen and Wei-yan Cai and Yan Guo and He-fei Huang and Xiao Xin Zhu},
  journal={Drug Design, Development and Therapy},
  pages={5301 - 5313}
  • Ya Wang, Qi Li, X. X. Zhu
  • Published 22 September 2015
  • Biology, Chemistry
  • Drug Design, Development and Therapy
Multidrug resistance (MDR) is the main obstacle limiting the efficacy of cancer chemotherapy. Looking for novel anti-MDR agents is an important way to conquer cancer drug resistance. We recently established that chamaejasmin B (CHB), a natural biflavone from Stellera chamaejasme L., is the major active component. However, its anti-MDR activity is still unknown. This study investigated the anti-MDR effect of CHB and the underlying mechanisms. First, it was found that CHB inhibited the growth of… 

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