Challenging the gold standard: should mannitol remain our first-line defense against intracranial hypertension?

@article{Infanti2008ChallengingTG,
  title={Challenging the gold standard: should mannitol remain our first-line defense against intracranial hypertension?},
  author={Jennifer L Infanti},
  journal={The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses},
  year={2008},
  volume={40 6},
  pages={362-8}
}
Mannitol has long been the "gold standard" for treatment of cerebral edema and refractory intracranial hypertension in traumatic brain injury, subarachnoid hemorrhage, and stroke. Studies performed in animals have shown that hypertonic saline (HS), in doses ranging from 3% to 10%, may be more effective than mannitol in treating these populations. Recently, randomized clinical trials have evaluated the efficacy and safety of HS versus mannitol in the treatment of elevated intracranial pressure… CONTINUE READING

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