Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology

@article{GomesdaSilva2013ChallengingTF,
  title={Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology},
  author={L. C. Gomes-da-Silva and S. Sim{\~o}es and J. Moreira},
  journal={Cellular and Molecular Life Sciences},
  year={2013},
  volume={71},
  pages={1417-1438}
}
  • L. C. Gomes-da-Silva, S. Simões, J. Moreira
  • Published 2013
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • The identification of numerous deregulated signaling pathways on cancer cells and supportive stromal cells has revealed several molecular targets whose downregulation can elicit significant benefits for cancer treatment. In this respect, gene downregulation can be efficiently achieved by exploiting the RNA interference mechanism, particularly by the delivery of chemical synthesized small-interfering RNAs (siRNAs), which have the ability to mediate, in a specific manner, the degradation of any… CONTINUE READING
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    References

    SHOWING 1-10 OF 148 REFERENCES
    Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges.
    • 154
    Non-viral lipid-based nanoparticles for targeted cancer systemic gene silencing.
    • 39
    Confirming the RNAi-mediated mechanism of action of siRNA-based cancer therapeutics in mice.
    • 298
    • PDF
    Overcoming the innate immune response to small interfering RNA.
    • 236
    • PDF
    Designer lipids advance systemic siRNA delivery.
    • Y. Liu, L. Huang
    • Biology, Medicine
    • Molecular therapy : the journal of the American Society of Gene Therapy
    • 2010
    • 24
    Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo.
    • 494
    • PDF
    RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
    • 169
    • PDF
    Safety profile of RNAi nanomedicines.
    • 92
    • Highly Influential
    Deciphering the code of innate immunity recognition of siRNAs.
    • M. Sioud
    • Biology, Medicine
    • Methods in molecular biology
    • 2009
    • 35