Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease.

@article{Coughlan2016ChallengingTD,
  title={Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease.},
  author={Melinda T. Coughlan and Kumar Sharma},
  journal={Kidney international},
  year={2016},
  volume={90 2},
  pages={272-279}
}
The paradigm that high glucose drives overproduction of superoxide from mitochondria as a unifying theory to explain end organ damage in diabetes complications has been tightly held for more than a decade. With the recent development of techniques and probes to measure the production of distinct reactive oxygen species (ROS) in vivo, this widely held dogma is now being challenged with the emerging view that specific ROS moieties are essential for the function of specific intracellular signaling… CONTINUE READING

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