Challenging the current approaches to multiple myeloma-related bone disease: from bisphosphonates to target therapy.

@article{Tassone2009ChallengingTC,
  title={Challenging the current approaches to multiple myeloma-related bone disease: from bisphosphonates to target therapy.},
  author={Pierfrancesco Tassone and Pierosandro Tagliaferri and Michela Rossi and Teresa Calimeri and Angela Bulotta and Alberto Abbruzzese and Michele Caraglia and Paola Neri},
  journal={Current cancer drug targets},
  year={2009},
  volume={9 7},
  pages={854-70}
}
Bone disease (BD) is the hall-mark clinical feature of multiple myeloma (MM), accounting up to 60% of patients with bone pain at diagnosis and 60% with a pathologic fracture during the course of their disease. Experimental models, which recapitulate in vivo the human bone marrow microenvironment (HBMM) in immunodeficient mice have been recently developed as valuable tool for the study of MM pathophysiology as well as the experimental treatment of BD. At present, bisphosphonates are the mainstay… CONTINUE READING

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