Challenging the clinical relevance of folinic acid over rescue after high dose methotrexate (HDMTX).

Abstract

THE HYPOTHESIS The use of adequate folinic acid rescue (in clinically relevant doses) after high dose methotrexate will prevent neurotoxicity without reducing treatment results. METHODS A literature search was performed to test the hypothesis that no evidence for the existence of folinic acid over-rescue of high-dose methotrexate (MTX) in clinically… (More)
DOI: 10.1016/j.mehy.2013.08.027

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