Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

@article{Dunne2016ChallengingTC,
  title={Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.},
  author={Philip D. Dunne and Darragh G. McArt and Conor A. Bradley and Paul G. O'Reilly and Helen L Barrett and Robert Cummins and Tony O'Grady and Ken Arthur and Maurice B Loughrey and Wendy L Allen and Simon McDade and David J. J. Waugh and Peter William Hamilton and Daniel Broderick Longley and Elaine W. Kay and Patrick Gerard Johnston and Mark Lawler and Manuel Salto-Tellez and Sandra van Schaeybroeck},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 16},
  pages={4095-104}
}
PURPOSE A number of independent gene expression profiling studies have identified transcriptional subtypes in colorectal cancer with potential diagnostic utility, culminating in publication of a colorectal cancer Consensus Molecular Subtype classification. The worst prognostic subtype has been defined by genes associated with stem-like biology. Recently, it has been shown that the majority of genes associated with this poor prognostic group are stromal derived. We investigated the potential for… CONTINUE READING
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EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2016

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