Challenging resistance mechanisms to therapies for metastatic melanoma.

  title={Challenging resistance mechanisms to therapies for metastatic melanoma.},
  author={Lucio Tentori and Pedro Miguel Lacal and Grazia Graziani},
  journal={Trends in pharmacological sciences},
  volume={34 12},
Melanoma is the most aggressive form of skin cancer and, if spread outside the epidermis, has a dismal prognosis. Before the approval of the anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) monoclonal antibody ipilimumab and the BRAF inhibitors vemurafenib and dabrafenib, no other agents had demonstrated better results in terms of overall survival than the DNA-methylating compound dacarbazine (or its oral analog temozolomide). However, most patients with metastatic melanoma do not… CONTINUE READING
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