Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections.

@article{Pascual2012ChallengingRO,
  title={Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections.},
  author={A. Delgado Pascual and Chantal Csajka and Thierry Buclin and Saskia Bolay and Jacques Bille and Thierry Calandra and Oscar Marchetti},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2012},
  volume={55 3},
  pages={
          381-90
        }
}
  • A. Delgado Pascual, Chantal Csajka, +4 authors Oscar Marchetti
  • Published in
    Clinical infectious diseases…
    2012
  • Medicine
  • BACKGROUND Recommended oral voriconazole (VRC) doses are lower than intravenous doses. Because plasma concentrations impact efficacy and safety of therapy, optimizing individual drug exposure may improve these outcomes. METHODS A population pharmacokinetic analysis (NONMEM) was performed on 505 plasma concentration measurements involving 55 patients with invasive mycoses who received recommended VRC doses. RESULTS A 1-compartment model with first-order absorption and elimination best fitted… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES

    NONMEM user’s guide

    • SL Beal, LB Sheiner, A Boeckmann, RJ. Bauer
    • Ellicott City, MD: Icon Development Solutions,
    • 2006
    VIEW 4 EXCERPTS
    HIGHLY INFLUENTIAL

    Population pharmacokinetics of voriconazole in adults.

    Voriconazole pharmacokinetics and pharmacodynamics in children.