Challenging a paradigm: the role of DNA homology in tyrosine recombinase reactions.

@article{Rajeev2009ChallengingAP,
  title={Challenging a paradigm: the role of DNA homology in tyrosine recombinase reactions.},
  author={Lara Rajeev and Karolina Malanowska and Jeffrey F. Gardner},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2009},
  volume={73 2},
  pages={300-9}
}
A classical feature of the tyrosine recombinase family of proteins catalyzing site-specific recombination, as exemplified by the phage lambda integrase and the Cre and Flp recombinases, is the ability to recombine substrates sharing very limited DNA sequence identity. Decades of research have established the importance of this short stretch of identity within the core regions of the substrates. Since then, several new enzymes that challenge this paradigm have been discovered and require the… CONTINUE READING