Challenges to accrual predictions to phase III cancer clinical trials: a survey of study chairs and lead statisticians of 248 NCI-sponsored trials.

@article{Schroen2011ChallengesTA,
  title={Challenges to accrual predictions to phase III cancer clinical trials: a survey of study chairs and lead statisticians of 248 NCI-sponsored trials.},
  author={Anneke T. Schroen and Gina R. Petroni and Honkung Wang and Monika J Thielen and Daniel J. Sargent and Jacqueline Benedetti and Walter M. Cronin and Donald Lawrence Wickerham and Xiaofei Wang and Robert W. Gray and Wendy F. Cohn and Craig L Slingluff and Benjamin Djulbegovic},
  journal={Clinical trials},
  year={2011},
  volume={8 5},
  pages={
          591-600
        }
}
BACKGROUND Research on barriers to accrual has typically emphasized factors influencing participation after trial activation. PURPOSE We sought to identify factors influencing trial design and accrual predictions prior to trial activation associated with sufficient accrual. METHODS A 30-question web-based survey was sent to the study chair and lead statistician for all 248 phase III trials open in 1993-2002 by five Clinical Trials Cooperative Groups. Questions addressed prior trial… CONTINUE READING
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