Challenges in using stem cells for cardiac repair.

  title={Challenges in using stem cells for cardiac repair.},
  author={Christine L Mummery and Richard P Davis and Jos{\'e} Eduardo Krieger},
  journal={Science translational medicine},
  volume={2 27},
Of the many diseases discussed in the context of stem cell therapy, those concerning the heart account for almost one-third of the publications in the field. However, the long-term clinical outcomes have been disappointing, in part because of preclinical studies failing to optimize the timing, number, type, and method of cell delivery and to account for shape changes that the heart undergoes during failure. In situations in which cardiomyocytes have been used in cell therapy, their alignment… CONTINUE READING

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