Challenges in translating endpoints from trials to observational cohort studies in oncology

@inproceedings{Ording2016ChallengesIT,
  title={Challenges in translating endpoints from trials to observational cohort studies in oncology},
  author={Anne G Ording and Deirdre Cronin-Fenton and Vera Ehrenstein and Timothy L Lash and John Acquavella and Mikael Rahbek R{\o}rth and Henrik Toft S{\o}rensen},
  booktitle={Clinical epidemiology},
  year={2016}
}
Clinical trials are considered the gold standard for examining drug efficacy and for approval of new drugs. Medical databases and population surveillance registries are valuable resources for post-approval observational research, which are increasingly used in studies of benefits and risk of new cancer drugs. Here, we address the challenges in translating endpoints from oncology trials to observational studies. Registry-based cohort studies can investigate real-world safety issues - including… CONTINUE READING

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