Challenges in the treatment of depression with psychotic features

  title={Challenges in the treatment of depression with psychotic features},
  author={Anthony J Rothschild},
  journal={Biological Psychiatry},
Major depression with psychotic features (MDpsy), a disorder with considerable morbidity and mortality, is more common than is generally realized and is a most difficult form of depression to treat. Patients with MDpsy exhibit more frequent relapses and recurrences and have increased use of services, greater disability, and a poorer clinical course when compared with nonpsychotically depressed patients. Patients with MDpsy demonstrate distinct biological abnormalities in studies of the… CONTINUE READING


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