Challenges in the diagnosis of the antiphospholipid syndrome.

  title={Challenges in the diagnosis of the antiphospholipid syndrome.},
  author={Katrien M J Devreese and Marc F Hoylaerts},
  journal={Clinical chemistry},
  volume={56 6},
BACKGROUND The antiphospholipid syndrome (APS) is an important cause of acquired thromboembolic complications and pregnancy morbidity. Its diagnosis is based on clinical and laboratory criteria, defined by strict guidelines. The original clinical and laboratory criteria for the identification of APS patients were published in 1999, in the so-called Sapporo criteria. In 2006 these criteria were revised, and recently more precise guidelines for analysis of the lupus anticoagulant have been… CONTINUE READING


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