Challenges in systematic reviews that assess treatment harms.

  title={Challenges in systematic reviews that assess treatment harms.},
  author={Roger Chou and Mark Helfand},
  journal={Annals of internal medicine},
  volume={142 12 Pt 2},
To be useful to decision makers, an evidence synthesis of a medical intervention should assess the balance of benefits and harms (1, 2). Harms from medical interventions include adverse drug events (3) and complications following surgery or other procedures. An evidence synthesis that emphasizes only benefits is likely to lead to biased conclusions (4). For most interventions, unfortunately, systematic reviews of harms are sparser than reviews of benefits. An analysis of more than 1000… CONTINUE READING


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