Challenges in predicting which oral mucosal potentially malignant disease will progress to neoplasia.

@article{Scully2014ChallengesIP,
  title={Challenges in predicting which oral mucosal potentially malignant disease will progress to neoplasia.},
  author={Crispian M Scully},
  journal={Oral diseases},
  year={2014},
  volume={20 1},
  pages={
          1-5
        }
}
Probably the greatest challenge to those managing patients with oral diseases is the dilemma of attempting to predict which oral erythroplakias, leukoplakias, lichenoid and other potentially malignant mucosal disease (PMD) such as oral submucous fibrosis will progress to neoplasia--notably oral squamous cell carcinoma (OSCC). The paper reviews progress over the past decade and the application to the clinical situation. 
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58 Citations

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Evaluation and Management of Oral Potentially Malignant Disorders.
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TLDR
The following review traces the evolution of the grading system of dysplasia, its relevance and clinical utility and suggests that a two-tier system may be more reproducible and clinically translatable for better management.
Myofibroblasts in oral potentially malignant disorders: Is it related to malignant transformation?
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Evidence is provided that immunodetection of myofibroblasts may identify oral submucous fibrosis (OSMF) with high risk of malignant transformation, but does not represent an auxiliary tool to predict the malignant potential of leukoplakia and erythroplakia, the most common OPMD.
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  • Medicine
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  • 2017
Oral leukoplakia remains a challenging condition.
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This review aims to provide a general overview on leukoplakia, explore current challenges in its diagnosis and management and discuss the opportunities to better understand the condition.
Survival study of leukoplakia malignant transformation in a region of northern Spain
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Dysplasia is the only risk factor that is statistically related to the development of a carcinoma and only location and initial dysplasia have a statistically significant relationship with malignant transformation.
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It is concluded that patients with OSCC associated with a precursor had significantly lower odds of dying from disease and the beneficial effect of precursor lesion diagnosis on outcome is related to a higher proportion of stage I disease.
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This series offers the primary care dental team an overview of the aetiopathogenesis, prevention, diagnosis and multidisciplinary care of mouth cancer, the functional and psychosocial implications, and minimization of the impact on the quality of life of patient and family.
Oral erythroplakia-What is it?
TLDR
A new approach to perceive the lesion is proposed based on the clinical features of a fiery red, sharply demarcated lesion situated at a slightly lower level than the surrounding mucosa, which would probably help clinicians distinguish erythroplakia from other red lesions of the oral mucosa.
Salivary micro RNA as a potential biomarker in oral potentially malignant disorders: A systematic review
TLDR
This systematic review explored the potential of expression of salivary miRNA in OPMD and revealed upregulated miRNA 184 with an area under the curve (AUC) of 0.86 and miRNA 21 with an AUC of0.68, which proved that these miRNAs are significant in detecting early malignancy in O PMD and should be further analyzed in various populations.
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