Challenges in developing endpoints for type 1 diabetes intervention studies.

@article{Cernea2009ChallengesID,
  title={Challenges in developing endpoints for type 1 diabetes intervention studies.},
  author={Simona Cernea and Itamar Raz and Kevan C Herold and Boaz Hirshberg and Bart O Roep and Desmond A Schatz and Gilbert Alexander Fleming and Paolo Pozzilli and Randie R Little and Nanette C Schloot and R David Leslie and Jay S Skyler and Jerry P. Palmer},
  journal={Diabetes/metabolism research and reviews},
  year={2009},
  volume={25 8},
  pages={
          694-704
        }
}
Development of efficient and safe intervention strategies for preserving and/or restoring endogenous insulin production in type 1 diabetes has encountered a wide range of challenges, including lack of standardized trial protocols and of consensus on appropriate efficacy endpoints. For the greatest part, difficulties resided in choosing the most suitable assay(s) and parameter(s) to assess the beta-cell function. It is now an accepted approach to evaluate endogenous insulin secretion by… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 80 REFERENCES

: licensed to kill ?

J Sherr, J Sosenko, JS Skyler, KC Herold
  • 2008