Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient

@inproceedings{Yukl2013ChallengesID,
  title={Challenges in Detecting HIV Persistence during Potentially Curative Interventions: A Study of the Berlin Patient},
  author={Steven A Yukl and Eli Boritz and Michael Busch and Christopher Bentsen and Tae-Wook Chun and Daniel C. Douek and Evelyn E. Eisele and Ashley Haase and Ya-Chi Ho and Gero H{\"u}tter and J. Shawn Justement and Sheila Keating and Tzong-Hae Lee and Peilin Li and Danielle D Murray and Sarah K. Palmer and Christopher Pilcher and Satish Pillai and Richard W. Price and Meghan B Rothenberger and Timothy W Schacker and Janet D Siliciano and Robert F. Siliciano and Elizabeth Sinclair and Matt Strain and Joseph Wong and Douglas R Richman and Steven G. Deeks},
  booktitle={PLoS pathogens},
  year={2013}
}
There is intense interest in developing curative interventions for HIV. How such a cure will be quantified and defined is not known. We applied a series of measurements of HIV persistence to the study of an HIV-infected adult who has exhibited evidence of cure after allogeneic hematopoietic stem cell transplant from a homozygous CCR5Δ32 donor. Samples from blood, spinal fluid, lymph node, and gut were analyzed in multiple laboratories using different approaches. No HIV DNA or RNA was detected… CONTINUE READING
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