Challenges for vaccination in the elderly

  title={Challenges for vaccination in the elderly},
  author={Richard J. Aspinall and Giuseppe Del Giudice and Rita B. Effros and Beatrix Grubeck-Loebenstein and Suryaprakash Sambhara},
  journal={Immunity & ageing : I & A},
  pages={9 - 9}
The increased susceptibility of the elderly to infection presents a major challenge to public health services. An aging immune system is well documented as the cause of increased infection rates in elderly people. Such immunosenescence is multi-factorial and incompletely understood. Immunosenescent changes include malfunctioning of innate immune system cellular receptors; involution of the thymus, with consequent reduction of the naïve T cell population; alteration of the T cell population… CONTINUE READING

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Naïve or not Naïve? Age related changes of human CD8+ T cells defined by the surface markers CD45RA, CD28 & CD62L

  • G Pfister
  • Innsbruck Medical University;
  • 2006
Highly Influential
4 Excerpts

Safety of high doses of influenza vaccine and Page 8 of 9 (page number not for citation purposes) Immunity

  • WA Keitel, RL Atmar, +4 authors RB Couch
  • Ageing
  • 2007
1 Excerpt

World population ageing 1950–2050

  • United Nations, Department of Economic, Social Affairs, Population Division
  • Report prepared for the 2nd World Assembly on…
  • 2007
1 Excerpt

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