Challenges associated with metal chelation therapy in Alzheimer's disease.

  title={Challenges associated with metal chelation therapy in Alzheimer's disease.},
  author={Muralidhar L Hegde and Polkampally Bharathi and Anitha Suram and Chitra Venugopal and Ramya Jagannathan and Pankaj Poddar and Pullabhatla Srinivas and Kumar Sambamurti and Kosagisharaf Jagannatha Rao and Janez {\vS}{\vc}an{\vc}ar and Luigi Messori and Luigi Zecca and Paolo Zatta},
  journal={Journal of Alzheimer's disease : JAD},
  volume={17 3},
A close association between brain metal dishomeostasis and the onset and/or progression of Alzheimer's disease (AD) has been clearly established in a number of studies, although the underlying biochemical mechanisms remain obscure. This observation renders chelation therapy an attractive pharmacological option for the treatment of this disease. However, a number of requirements must be fulfilled in order to adapt chelation therapy to AD so that the term "metal targeted strategies" seems now… CONTINUE READING

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