Challenges and opportunities in the development of protein phosphatase-directed therapeutics.


Protein phosphatases have both protective and promoting roles in the etiology of diseases. A prominent example is the existence of oncogenic as well as tumor-suppressing protein phosphatases. A few protein phosphatase activity modulators are already applied in therapies. These were however not developed in target-directed approaches, and the recent… (More)
DOI: 10.1021/cb300597g


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