Challenges and directions for the pathogen hypothesis of Alzheimer’s disease

@article{Robinson2004ChallengesAD,
  title={Challenges and directions for the pathogen hypothesis of Alzheimer’s disease},
  author={Stephen R. Robinson and Curtis B Dobson and Joseph M. Lyons},
  journal={Neurobiology of Aging},
  year={2004},
  volume={25},
  pages={629-637}
}
Pathogens as a cause of Alzheimer’s disease
Alzheimer ' s disease and the role of infectious Agents : A review
TLDR
It is suggested that some infectious agents, may contribute to the pathogenesis of AD and with the prevention and treatment of such infectious agents the sanitation authorities can decrease the risk of AD.
Role of Infection in the Pathogenesis of Alzheimer’s Disease
TLDR
This work has shown that peripheral infections may have a role to play in accelerating neurodegeneration in Alzheimer’s disease by activating already primed microglial cells within the CNS.
Is Alzheimer's disease an infectious neurological disease? A review of the literature.
TLDR
An overview of new findings around the relationship between microorganisms and AD, challenges facing the validity of the theory, and recommendations on how the scientific community can best develop alternative approaches to address the pathophysiology of AD are provided.
Chlamydophila pneumoniae Infection and Its Role in Neurological Disorders
TLDR
The demonstration of C. pneumoniae by histopathological, molecular and culture techniques in the late-onset AD dementia has suggested a relationship between CNS infection with C. tuberculosis and the AD neuropathogenesis, and the role of Chlamydia in the pathogenesis of mental or neurobehavioral disorders including schizophrenia and autism is uncertain and fragmentary and will require further confirmation.
Association of Alzheimer's disease and Chlamydophila pneumoniae.
Anti-Viral Properties of Amyloid-β Peptides.
TLDR
The data that support the interpretation that A β peptides behave as AMP are reviewed, with an emphasis on studies concerning HSV-1 and a putative molecular mechanism that suggests that interactions between Aβ peptides and the HSv-1 fusogenic protein gB lead to impairment of HSVs infectivity by preventing the virus from fusing with the plasma membrane.
Alzheimer's Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence.
TLDR
The antimicrobial role of Aβ may explain why increased rates of infection have been observed in some of the AD clinical trials that depleted Aβ, and progress toward a cure for AD will accelerate once treatment strategies begin to take into account the likely physiological functions of this enigmatic peptide.
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