Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy.

@article{Skrombolas2014ChallengesAD,
  title={Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy.},
  author={Denise Skrombolas and John G. Frelinger},
  journal={Expert review of clinical immunology},
  year={2014},
  volume={10 2},
  pages={
          207-17
        }
}
Interleukin-2 (IL-2) is a cytokine with pleiotropic effects on the immune system. Systemic IL-2 treatment has produced durable responses in melanoma and renal cancer patients, but unfortunately this is effective only in a fraction of patients. Moreover, IL-2 treatment also engenders serious side effects, which limit its clinical utility. It is now appreciated that IL-2 not only stimulates NK and effector T cells but also has a critical role in the generation and maintenance of regulatory T… CONTINUE READING
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