Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review

@article{Lafountaine2015ChallengesAS,
  title={Challenges and Strategies in Thermal Processing of Amorphous Solid Dispersions: A Review},
  author={Justin S. Lafountaine and James William Mcginity and Robert O Williams},
  journal={AAPS PharmSciTech},
  year={2015},
  volume={17},
  pages={43-55}
}
Thermal processing of amorphous solid dispersions continues to gain interest in the pharmaceutical industry, as evident by several recently approved commercial products. Still, a number of pharmaceutical polymer carriers exhibit thermal or viscoelastic limitations in thermal processing, especially at smaller scales. Additionally, active pharmaceutical ingredients with high melting points and/or that are thermally labile present their own specific challenges. This review will outline a number of… CONTINUE READING
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